First screening
Pharmacology: Irwin modified test (mouse)
Behavioral phenotyping : Primary screen (mouse)
Acute toxicity : LD50 (mouse, rat)
Spontaneous activity in an open field (mouse, rat)
Long-term follow-up
Telemetric measurement of activity, temperature, heart rate (mouse)
Activity in an open-field (mouse, rat)
Learning – Memory (working/reference/episodic memory – spatial/non spatial – habituation)
Object recognition (mouse, rat) Click here to see the test
Passive avoidance (mouse)
Spontaneous alternation in a Y-maze (mouse) Click here to see the test
Place recognition in a Y-maze (rat)
Habituation in an open-field (mouse, rat)
One-trial learning in an elevated plus maze (mouse)
Morris water maze – Acquisition – Reference memory – Working memory (mouse, rat)
Radial maze – Acquisition – Reference memory – Working memory (mouse, rat)
Radial maze –Working/episodic memory : Delayed-Non-Matching-To-Sample (rat)
Drug Abuse - Pharmacodependence
Behavioral sensitization (mouse, rat)
Place preference (mouse, rat)
Opiate withdrawal (mouse, rat)
Benzodiazepine withdrawal (mouse) Click here to see the test
Alcohol withdrawal (mouse, rat)
Alcohol consumption (mouse)
Opiate self administration (mouse) Click here to see the test
Depression
Forced swimming test (mouse, rat) - Click here to see the test
Tail suspension test (mouse)
Chronic mild stress (mouse) - Click here to see the test
Anxiety
Elevated plus maze (mouse, rat) Click here to see the test
Light/dark box (mouse) Click here to see the test
Four plates test (mouse)
Marble burying test (mouse) Click here to see the test
Stress induced hyperthermia (mouse) Click here to see the test
Anxiety swim stress (rat) Click here to see the test
Psychosis
Catalepsy
Antagonism of effects (hypothermia, stereotypies, hyperactivity) of apomorphine (mouse)
Antagonism of hyperactivity-induced by MK-801 (mouse)
Antagonism of PCP-induced stereotypies (mouse)
Motor
Rotarod (mouse, rat)
Grip strength (mouse)
Locomotor activity (mouse, rat)
Attention – Impulsivity
Five-choice reaction time (mouse)
Impulsive behaviours : ADHD, suicide, OCD
Waiting ability in a T-maze (rat) - Click here to see the test
Pain – Inflammation
Sickness behavior induced by LPS (rat)
Pain, see partners
Neurodegenerative diseases (Alzheimer – Parkinson – Huntington chorea) and aging
Aging : memory deficits induced by age (mouse, rat)
Alzheimer disease : memory deficits induced by scopolamine (mouse, rat)
Alzheimer disease : memory deficits induced by β-amyloid protein (rat)
Parkinson disease : motor deficits and dopamine depletion induced by MPTP (mouse)
Huntington chorea : motor deficits induced by 3-NP (rat) - Click here to see the test
Immunology
Key Obs offers in collaboration with its partner laboratory at CNRS in Orleans (partnership agreement CNRS/081.1722.00 IEM2815), a broad spectrum of preclinical services in immunology with an emphasis on lung diseases, infectious diseases, immunological and morphological investigations.
Allergic asthma
Acute respiratory distress syndrome (ARDS)
Chronic obstructive pulmonary disease (CPOD)
Lung emphysema and fibrosis
Immune complex alveolitis
