News
A wider range of tests available for investigating anxiety and anti-stress substances
- Elevated plus maze - Light/dark box - Four-plate
and now
- Stress-induced anxiety in Elevated Plus Maze - Stress-induced hyperthermia
- Marble burying test Feel free to ask further information
Key-Obs proposes a new model for testing of drugs for ADHD : the test of waiting ability in a T-maze in juvenile rats. This model is now validated with methylphenidate and atomoxetine.
LAST PUBLICATIONS
Respiratory diseases
A new publication involving Key-Obs, available on line on the web site of The Journal of Clinical Investigation
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
By Pamela Gasse, Caroline Mary, Isabelle Guenon, Nicolas Noulin, Sabine Charron, Silvia Schnyder-Candrian, Bruno Schnyder, Shizuo Akira, Valérie F.J. Quesniaux, Vincent Lagente, Bernhard Ryffel and Isabelle Couillin
In this publication, by using models of lung inflammation, it is demonstrating that bleomycin-induced lung pathology requires the inflammasome and IL-1R1/MyD88 signaling. Furthermore, this work shows that IL-1 represents a critical effector of pathology and therapeutic target of chronic lung inflammation and fibrosis.
In partnership with the CNRS team, Key-Obs offers the mouse models of respiratory diseases used in the paper for testing of active compounds.
Parkinson disease Sonnier, L.; Le Pen, G.; Hartmann, A.; Bizot, J. C.; Trovero, F.; Krebs, M. O.; Prochiantz, A. Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. J Neurosci. 2007, 27, 5, 1063-71
NEW! In compliance with the "Guideline of the non-clinical investigation of the dependence potential of medecinal products" (European Medicines Agency/CHMP/SWP/94227/2004), Key-Obs offers a series of preclinical tests dedicated to the evaluation of pharmacodependence potential. Contact us.
